Granulophysin

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WebSep 1, 1992 · Granulophysin levels were only low in forms of delta-SPD associated with albinism. Granulophysin levels in platelet homogenates of 30 patients with the Hermansky-Pudlak syndrome form of delta-SPD were 1/4 to 1/5 of levels in controls or obligate heterozygotes. Two patients with the Chediak-Higashi form of delta-SPD syndrome also … WebThe H5C6 monoclonal antibody specifically binds to CD63. CD63 is a 53 kDa, type III lysosomal glycoprotein, expressed on activated platelets, monocytes and macrophages. This molecule is also referred to in the literature as LIMP, gp55, melanoma-associated antigen ME491, Pltgp40, LAMP-3 and is a member of the tetraspan transmembrane 4 …

(PDF) The protein CD63 is in platelet dense granules, is

Webgp55; granulophysin; Lysosomal-associated membrane protein 3 (LAMP-3); Mast cell antigen AD1; Melanoma-associated antigen ME491; MLA1; NGA; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin-30; TSPAN30. Positive Control. SK-MEL-28, HL60, THP-1 or NIH/3T3 cells. Human spleen or lymphoma tissue (IHC). WebCD63 was first described in granules of resting platelets and on the surface membrane on activated platelets. CD63 was later identified as granulophysin, a platelet dense granule glycoprotein. The molecular … simple one electric scooter in hyderabad

Platelet dense granule membranes contain both granulophysin …

WebGranulophysin (CD63) is a protein in the tetraspanin group and is found in, among others, the dense granules and the α-granules of platelets [139,140], as well as the azurophilic granules of ... WebJul 1, 1992 · We recently reported the characterization of a platelet granule membrane protein of molecular weight (mol wt) 40,000 called granulophysin (Gerrard et al: Blood … WebThe immunological crossreactivity between the two granule‐specific membrane glycoproteins, synaptophysin and granulophysin, was studied using a series of … ray ash park chicopee

PE-Cy™7 Mouse Anti-Human CD63 - BD Biosciences

Granulopoiesis - an overview ScienceDirect Topics

WebAnti-CD63 (LAMP3), clone ME491, Cat. No. MABF2159, is a mouse monoclonal antibody that detects CD63 antigen and has been tested for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting. Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot … WebHuman CD63 antigen, also referred to as Granulophysin, Lysomal-associated membrane protein 3 (LAMP-3), Tetraspanin-30, and Ocular melanoma-associated antigen, is a membrane bound protein encoded by the gene CD63. CD63 belongs to a group of proteins known as the tetraspanin family, which are characterized by the presence of four … ray ashton tax service amarillo txWebApr 1, 1993 · The levels and expression of the proteins CD63 and granulophysin in platelets from control and from a Hermansky-Pudlak syndrome subject (a condition characterized by dense granule and lysosomal deficiencies and the accumulation of ceroid-like material in reticuloendothelial cells) were examined. Immunofluorescence studies … rayas hotel

"Webgranulophysin (uncountable) (biochemistry) A membrane protein sometimes present in blood platelets " - Granulophysin

Granulophysin

WebView application images and datasheets for 1333 anti Granulophysin Antibody antibodies from 38 leading antibody suppliers, plus reviews and the top related antibodies WebJun 1, 1997 · Granulophysin labels the dense granule membrane (D) but not the α-granules (A). Gp Ib is found essentially along the plasma membrane (pm). The OCS and some α-granules (A) are occasionaly labeled. It also double-labels the dense granule membrane (D) identified by the presence of granulophysin. (Original magnification × …

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WebJun 1, 1994 · Abstract. Granulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal … WebBrand: BD Pharmingen™ Alternative Name: LAMP-3; ME491; MLA-1; Granulophysin; Ptgr40; NGA; gp55 Reactivity: Human (QC Testing), Rhesus, Cynomolgus, Baboon …

WebDec 26, 2024 · Design and methods: The analysis of platelet surface proteins (Glycoprotein Ib-IX (CD42b, CD42a), Glycoprotein IIb-IIIa (CD41, CD61), p-selectin (CD62P), … WebPE-Cy7 is a tandem fluorochrome composed of R-phycoerythrin (PE), which is excited by 488-nm light and serves as an energy donor, coupled to the cyanine dye Cy7, which acts as an energy acceptor and fluoresces maximally at 780 nm. PE-Cy7 tandem fluorochrome emission is collected in a detector for fluorescence wavelengths of 750 nm and higher.

WebNov 6, 2024 · Level of granulophysin on the platelet surface. A, 5‐ HT /catecholamine‐treated or ‐untreated platelets were evaluated by measuring the level of granulophysin, a surrogate marker for dense‐granule … Webmolecule, CD63_HUMAN, gp55, Granulophysin, LAMP 3, LAMP-3, LAMP3, LIMP, Lysosomal-associated membrane protein 3, Lysosome associated membrane glycoprotein 3, Mast cell antigen AD1, ME491, Melanoma 1 antigen, Melanoma associated antigen ME491, Melanoma associated antigen MLA1, Melanoma-associated antigen ME491, …

WebTarget Information. CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation …

WebJun 15, 2000 · Arrowheads indicate granulophysin (10-nm gold particles), and arrows indicate α-granule marker von Willebrand factor (5-nm gold particles). Both proteins can be found within the same MVB, but they are segregated from each other in distinct microvesicles. Granulophysin is also preferentially associated with the limiting … ray ashworth obituaryWebCD63 molecule. Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and ... rayas in spanishWebGRANULOPHYSIN HGNC Approved Gene Symbol: CD63 Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,723,535-55,730,041 (from NCBI) TEXT Cloning … ray ash park chicopee maWebGranulophysin Lysosomal-associated membrane protein 3 LAMP-3 Melanoma-associated antigen ME491 OMA81H Ocular melanoma-associated antigen Tetraspanin-30 Tspan-30 CD antigen CD63. From Uniport. CD63 Gene family protein . CD molecules . Approved symbol Common name; BTN3A1: BTN3A1 protein, recombinant: LAMP1: ray asmar obituaryWebNormal human peripheral blood cells were stained with CD193 (CCR3) Monoclonal Antibody, PE (Product # 12-1939-42) and IgE Monoclonal Antibody, FITC (Product # 11-6986-42) only (blue histogram), or stained with CD63 Monoclonal Antibody, NovaFluor Red 700 (Product # H074T03R03) (purple histogram). simple one electric scooter waiting periodWebJun 1, 1994 · Granulophysin expression on the surface membrane of the neutrophil is increased following stimulation of the cells, demonstrated by flow cytometry and fine structural immunocytochemistry. A similar pattern is shown for an anti-CD63 antibody. Incubation of activated neutrophils with D545, a monoclonal antibody to granulophysin, … simple one electric scooter test rideWebprotein called granulophysin ( 15, 16), which is decreased in the Hermansky-Pudlak syndrome (15, 17). Ourresults thus providethefirstidentification … ray ashton rugby league